Colchicine for acute gout.
نویسندگان
چکیده
Evidence-Based Answer Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout. However, it has not been compared with nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids in clinical trials. Concerns include high cost, drug-drug interactions, and potential toxicity. (Strength of Recommendation: B, based on inconsistent or limited-quality patient-oriented evidence.)
منابع مشابه
Colchicine in acute gouty arthritis: the optimum dose?
We applaud Cronstein and Terkeltaub [1] on their comprehensive review of the inflammatory process of gout and its treatment. Although they allude to the fact that colchicine probably has the smallest therapeutic window of any drug used to treat acute gouty arthritis, they have suggested " In treating acute gouty arthritis colchicine is typically administered as an oral 0.6 mg dose, followed by ...
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This series of articles facilitated by the Cochrane Musculoskeletal Group (CMSG) aims to place the findings of recent Cochrane musculoskeletal reviews in a context immediately relevant to general practitioners. This article considers the place of colchicine in the management of acute gout.
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A definitive diagnosis of acute gout is made by detection of monosodium urate crystals in the synovial fluid of an inflamed joint. However, when this is not feasible a clinical diagnosis can sometimes be made with reasonable accuracy. The mainstays of acute gout management are colchicine, NSAIDs, and systemic or intra-articular corticosteroids. NSAIDs are preferable to colchicine because of the...
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INTRODUCTION In spite of being the fastest acting drug available for the control of an acute gout attack, colchicine is generally considered a last alternative in gout therapy. This is mainly due to the severe adverse effects associated with its administration through the enteral and parenteral routes, as well as its high risk/benefit ratio. The preparation of dosage forms of colchicine that ca...
متن کامل“Gangrenous Finger” Proven to be Acute Gout
DESCRIPTION A 64-year-old woman was transferred from an outlying facility with a diagnosis of a " gan-grenous finger. " She complained of 1 week of worsening left small finger pain, erythema, and swelling. Aspiration was performed upon transfer, and she received a diagnosis of acute gout. Oral colchicine and prednisone were begun with great improvement.
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ورودعنوان ژورنال:
- American family physician
دوره 91 11 شماره
صفحات -
تاریخ انتشار 2015